Novel GTF2I – PDGFRB and IKZF1 – TYW1 fusions in pediatric leukemia with normal karyotype

ConclusionsThe examined pediatric leukemia is a Ph-like ALL which carries novelGTF2I–PDGFRB andIKZF1–TYW1 fusion genes together with additional submicroscopic deletions. Because hematologic neoplasms withPDGFRB-fusion genes can be treated with tyrosine kinase inhibitors, the detection of such novel fusions may be clinically important. Since theGTF2I–PDGFRB could be detected only after molecular studies of the leukemic cells, further investigations of ALL-cases, perhaps especially but not exclusively with a normal karyotype, are needed in order to determine the frequency ofGTF2I–PDGFRB in leukemia, and also to find out which clinical impact the fusion may have.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research