Antibiotic alternative shows promise
UK researchers discover new compound which kills antibiotic-resistant superbugs Related items fromOnMedica GPs given help to spot Lyme disease Single-dose malaria drug eliminates parasite from liver TB could be cured by four months ’ treatment in many patients Antibiotics courses often longer than guidelines 'Keep Antibiotics Working' campaign resurfaces
Publication date: Available online 10 October 2020Source: Journal of Genetics and GenomicsAuthor(s): Chengqi Wang, Justin Gibbons, Swamy R. Adapa, Jenna Oberstaller, Xiangyun Liao, Min Zhang, John H. Adams, Rays H.Y. Jiang
Authors: Abdeta D, Kebede N, Giday M, Terefe G, Abay SM Abstract Microbial resistance to the few conventional antitrypanosomal drugs, increasing resistance of vectors to insecticides, lack of effective vaccines, and adverse effects of the existing antitrypanosomal drugs justify the urgent need for effective, tolerable, and affordable drugs. We assessed antitrypanosomal effects of the hydromethanolic extract of Echinops kebericho Mesfin roots against Trypanosoma congolense field isolate using in vitro and in vivo techniques. Parasite load, packed cell volume (PCV), body weight, and rectal temperature in Swiss albino...
Conclusion: This study demonstrates that the crude extract of A. hispidum DC, one of the plants used traditionally to treat malaria, inhibits the growth of P. falciparum in vitro and could be a potential source of antimalarial drug. The report has highlighted genotoxic and cytotoxic effects of the selected plant extracts on human leukocytes as well. PMID: 33029160 [PubMed]
(Nagoya University) Using the model Orobanchaceae parasitic plant Phtheirospermum japonicum, scientists have discerned the molecular mechanisms underlying plant parasitism and cross-species grafting, pinpointing enzymeβ-1,4-glucanase (GH9B3) as an important contributor to both phenomena. Targeting this enzyme may help control plant parasitism in crops.
CONCLUSION: There is a high prevalence of MRSA causing abscesses in the Hispanic population evaluated in an ED in Puerto Rico. Systemic antibiotic use for the treatment of skin abscesses after incision and drainage remains high despite published guidelines arguing against their widespread use. Clindamycin resistance in our patient population appears to be more frequent than previously reported. PMID: 33031694 [PubMed - as supplied by publisher]
Conclusions: The low prevalence of asymptomatic malaria parasite carriage by the children living in the Cape Coast Metropolis suggests that the malaria control interventions in place in CCMA are highly effective and that additional malaria control interventions are required for the KEEA district to reduce the prevalence of asymptomatic malaria parasite carriers. No molecular evidence of P. ovale and P. vivax was identified in the afebrile children sampled from the selected schools. PMID: 33029151 [PubMed]
U.S. Centers for Disease Control and Prevention officials announced Friday what they describe as a " national action plan " to fight antibiotic-resistant infections.
Steve Lindsay, a public health entomologist at Durham University, is midway through explaining how dogs might play a role in detecting COVID-19 infections when a decidedly less-well trained canine interrupts our conversation. “If you’ll excuse me for a minute, I’ve got a naughty black Labrador out in the back garden doing something it shouldn’t be doing,” Lindsay says. He disappears. I hear barking. He returns accompanied by a chocolate lab. “She’s not as skilled as the detection dogs,” Lindsay says as the pup tries to lick his face. “But it’s really interesting t...
This study determined the level of ownership and usage of ITNs and associated factors among households in the Sunyani West district two years after the mass distribution campaign. Methods: Study participants were identified using the systematic approach in all five subdistricts of the Sunyani West district and interviewed, and data were collected on household ITN ownership. Data were also collected on the source of the ITN and whether the respondent slept under an ITN the previous night. Data on individual and community factors associated with ITN ownership and usage were also collected. Pearson chi-square tests and lo...
Research has found strains of Klebsiella pneumoniae resistant to the carbapenems spreading through hospitals Related items fromOnMedica GPs given help to spot Lyme disease Single-dose malaria drug eliminates parasite from liver Antibiotic research programme launched Measles cases triple in Europe but immunisation rates grow Chief medical officer launches push for flu jab drive