The rise of peripheral T helper cells in autoimmune disease

Nature Reviews Rheumatology, Published online: 28 May 2019; doi:10.1038/s41584-019-0241-7Studies across multiple autoimmune diseases, including rheumatoid arthritis and coeliac disease, have identified a pathologically expanded PD1hiCXCR5−CD4+ T cell population that accumulates in inflamed tissues. Can this peripheral T helper cell population be harnessed as a predictive biomarker or targeted therapeutically in these diseases?

Source: Nature Reviews Rheumatology - May 27, 2019 Category: Rheumatology Authors: Deepak A. Rao Source Type: research