Dissecting the molecular pathways of apoptosis in mesenchymal stromal cell therapy

ConclusionUsing pharmacological compounds that selectively inhibit pro-survival proteins to induce apoptosis in MSCs, we show that mouse and human bone marrow (BM) MSCs engage different molecules for survival. In addition, we are genetically manipulating the apoptotic pathways in mouse and human BM MSCs to gain a greater understanding of how these cells exert their therapeutic effects in vivo, an outstanding question in MSC therapy.
Source: Cytotherapy - Category: Cytology Source Type: research