Pelvic RT Versus Prophylactic Extended-field RT in Patients With Cervical Cancer

Condition:   Uterine Cervical Neoplasms Interventions:   Radiation: Prophylactic extended-field Irradiation;   Radiation: Pelvic irradiation;   Radiation: Intracavitary brachytherapy;   Drug: Concurrent chemotherapy Sponsors:   Peking Union Medical College Hospital;   Peking University First Hospital;   Cangzhou Central Hospital;   The Second Affiliated Hospital of Dalian Medical University;   Tumor Hospital of Gansu;   First Affiliated Hospital of Guangxi Medical University;   Harbin Medical Universi ty Third Affiliated Hospital;   Wuhan Union Hospital, China;   First Affiliated Hospital of Chongqing Medical University;   Guizhou Provincial People's Hospital;   Second Hospital of Jilin University;   China-Japan Union Hospital, Jilin University;   Jilin Provincial Tumor Hos pital;   Jiangsu Cancer Institute & Hospital;   The 940th Hospital of Joint Logistics Support Forceļ¼ŒPLA.;   General Hospital of Benxi Iron&Steel Industry Group;   The Affiliated Hospital of Inner Mongolia Medical University;   General Hospital of Ningxia Medical University;   Beijing Obstetrics and Gynecology Hospital;   Tangshan&nb...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Conclusions: The clinical results suggest that IMRT concurrent with chemotherapy isan effective treatment with acceptable toxicity for advanced cervical cancer with positive lymph nodes.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Uterine Cervical Neoplasms Interventions:   Radiation: Prophylactic extended-field Irradiation;   Radiation: Pelvic irradiation;   Radiation: Intracavitary brachytherapy;   Drug: Concurrent chemotherapy Sponsors:   Peking Union Medical College Hospital;   Peking University First Hospital;   Cangzhou Central Hospital;   The Second Affiliated Hospital of Dalian Medical University;   Tumor Hospital of Gansu;   First Affiliated Hospital of Guangxi Medical Univer...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Hypoxia is a poor prognostic factor in multiple tumor types. Hypoxic tumors are more resistant to radiation and chemotherapy and are more likely to develop distant metastases. Radiation resistance is of particular interest in cervical cancer, as baseline tumor hypoxia has been shown to be prognostic for local failure and survival in patients treated with primary radiotherapy.1 In vivo studies have shown that radiation resistance may be overcome by increasing the delivered radiation dose by a factor of 2-3.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Locally advanced cervical cancer is treated with external beam radiotherapy (EBRT) with concomitant cisplatin chemotherapy followed by high dose rate (HDR) image guided adaptive brachytherapy (IGABT). Modern radiotherapy techniques allow dose escalation to involved pelvic lymph nodes during EBRT. The aim of this project was to evaluate the contribution of IGABT to the nodal volumes and assess this against our current nodal prescriptions.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Conclusions: 3D-HDR-BT achieves favorable clinical outcomes with mild late toxicity in patients with locally rNPC. Introduction Nasopharyngeal carcinoma (NPC), a tumor of epithelial origin, is a malignant disease of the head and neck common in southern China, especially in Guangdong province (1). As a result of advances in modern imaging and irradiation techniques, the 5-year overall survival (OS) of patients with newly diagnosed NPC without metastasis has reached 75% after external beam radiotherapy (EBRT) in Asia (2, 3). However, local recurrence, which occurs in 18–40% of patients, remains a major reason for...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Current recommendation for locally advanced cervical cancer includes pelvic external beam radiation therapy (EBRT) with concurrent chemotherapy followed by brachytherapy. Involvement of pelvic lymph nodes is a...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Publication date: Available online 27 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Lisa A. Rubinsak, Mishka Terplan, Caitlin E. Martin, Emma C. Fields, William P. McGuire, Sarah M. TemkinAbstractThe purpose of this study was to identify the prevalence of substance use disorder and its association with adherence to treatment and survival in locally advanced cervical cancer patients treated with primary radiation therapy. This is a retrospective case series of locally advanced cervical cancer patients with substance use disorder in a single academic institution treated with radiation therapy between 2005 and 2016...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
ConclusionsNeoadjuvant chemoradiation therapy effectively downstages the majority of locally advanced type II endometrial cancers, thereby increasing the likelihood of achieving complete resection with negative margins.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
MONDAY, March 25, 2019 -- The current standard of care (SOC) for advanced cervical cancer -- external beam radiation therapy (EBRT) and chemotherapy in combination with brachytherapy -- provides significantly higher overall survival over...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionsThe18FDG-PET/CT influenced stage assessment and RT treatment planning due to its high specificity in distant metastases and nodal involvement detection. The IMRT with SIB for positive nodes was an effective therapy with acceptable toxicity in LACC.
Source: La Radiologia Medica - Category: Radiology Source Type: research
More News: Academies | Brachytherapy | Cancer | Cancer & Oncology | Cervical Cancer | Chemotherapy | China Health | Hospitals | Iron | Mongolia Health | OBGYN | Research