Immune reconstitution inflammatory syndrome causing progressive optic nerve edema in cryptococcal meningitis

Conclusion: Recurrent optic disk edema with loss of vision after treatment of cryptococcal meningitis in the setting of normal intracranial pressure may represent a unique manifestation of immune reconstitution inflammatory syndrome localized to the optic nerve without uveitis. This is consistent with the temporal relationship between starting highly active antiretroviral therapy, CD4+ count recovery, and the development of progressive disk edema in the study patient. Isolated optic nerve inflammation as a manifestation of immune reconstitution inflammatory syndrome has not been widely reported.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research