Association Between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly Diagnosed Essential Hypertension

Objective: Non-dipper hypertension (HT) confers greater risk compared with dipper hypertension. Growth differentiation factor 15 (GDF-15) recently emerged as a novel and independent marker of cardiovascular disease, both in diagnostic and prognostic scopes. Our aim was to evaluate the relationship of circadian blood pressure (BP) pattern with serum GDF-15 level in newly diagnosed HT patients without left ventricular hypertrophy. Subjects and Methods: Newly diagnosed non-dipper (n = 66) and dipper (n = 60) HT patients were selected according to 24-hour ambulatory blood pressure monitoring (ABPM). Healthy normotensive subjects (n = 31) comprised the controls. Data was collected through physical examination, laboratory analysis, ABPM and echocardiography. GDF-15 was measured using ELISA. Results: Greater GDF-15 level was found in the non-dippers, compared with the dippers and the controls (557.53 ±91.7 ng/L, 513.79±62.86 ng/L, and 494.44±79.30 ng/L, respectively, p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research