Chapter 4 - The use of nanomaterials for the mitigation of pathogenic biofilm formation

Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Aaron Elbourne, Vi Khanh Truong, Samuel Cheeseman, Piumie Rajapaksha, Sheeana Gangadoo, James Chapman, Russell J. CrawfordAbstractAntimicrobial resistance (AMR) has been identified as one of the greatest threats to human health (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). Unfortunately, the current rise in AMR has made biofilm-related infections a primary health-care concern, since these biofilms can no longer be effectively treated using conventional antibiotic methods (Azeredo et al., 2017, Costerton et al., 1999, Tuson and Weibel, 2013). If this rise in resistance goes unchecked, a return to the “pre-biotic era” would render infections untreatable and would significantly impact current practice in surgery, intensive care, organ transplantation, neonatology and cancer treatment through major increases in morbidity and mortality (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). In response, many research programs have departed from the development of new antibiotics, but have rather moved towards the exploitation of nanotechnology in the quest for next-generation methods for the prevention of biofilm formation (Elbourne et al., 2017, Tripathy et al., 2017). This change has taken place because many nanotechnologies, such as in the f...
Source: Methods in Microbiology - Category: Microbiology Source Type: research

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e C Abstract The zebrafish is a powerful vertebrate model for genetic studies on embryonic development and organogenesis. In the last decades, zebrafish were furthermore increasingly used for disease modeling and investigation of cancer biology. Zebrafish are particularly used for mutagenesis and small molecule screens, as well as for live imaging assays that provide unique opportunities to monitor cell behavior, both on a single cell and whole organism level in real time. Zebrafish have been also used for in vivo investigations of human cells transplanted into embryos or adult animals; this zebrafish xenograft mo...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 13 June 2019Source: Stem Cell ReportsAuthor(s): Lu Tian, Marie-José Truong, Chann Lagadec, Eric Adriaenssens, Emmanuel Bouchaert, Hélène Bauderlique-Le Roy, Martin Figeac, Xuefen Le Bourhis, Roland P. BouretteSummaryDuring normal mammary gland development, s-SHIP promoter expression marks a distinct type of mammary stem cells, at two different stages, puberty and early mid-pregnancy. To determine whether s-SHIP is a marker of mammary cancer stem cells (CSCs), we generated bitransgenic mice by crossing the C3(1)-SV40 T-antigen transgenic mouse model of breast cancer, a...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
(ERA-EDTA) While a kidney transplant can restore healthy kidney function, recipients remain at increased risk of fractures, heart disease, diabetes and some cancers. The VITALE study shows that, compared with currently recommended doses, high doses of oral vitamin D? (cholecalciferol) lower the risk of fractures, but have no effect on the risks of heart disease, diabetes or cancer after a kidney transplant [1].
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Philip McCarthy MD @plmcarthymd Of Roswell Park Comprehensive Cancer Center Discusses Updates On The FORTE Trial: 3 Arm Study, Higher Amount Of Persistent MRD At One Year In Patients Who Received A Tr... Author: Annual-Meeting Added: 06/13/2019
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Conclusion: Our data indicate that the risk of microvascular invasion is highest in tumors localized to segment 8. The size and number of HCC tumors were not associated with an increased risk of microvascular invasion. PMID: 31186641 [PubMed]
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
PMID: 31197384 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Worldwide, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely used as a therapeutic approach to treat hematological diseases. However, the associated morbi-mortality is a concern. In this context, there are different factors, mostly clinical characteristics, associated with outcomes of allo-HSCT. Nonetheless, some patient and donor demographic variables have been described to have prognostic impact [1]. Further, since almost two decades, the socioeconomic status (SES) has been associated with outcomes in cancer [2].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Conclusion: These results suggested that Gal combined with EcN might be a novel therapeutic approach with great potential of clinical implications for cancer prevention or treatment.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusion: Our results reveal an unexpected function of RIP3 in enhancing the proliferation of premalignant intestinal epithelial cells (IECs) and promoting myeloid cell-induced adaptive immune suppression. These two distinct mechanisms of RIP3-induced JNK and CXCL1 signalling contribute to CAC progression.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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