Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: a randomized controlled experimental study

ConclusionIntrathecal (S)-(+)-Ketoprofen caused dose-dependent neurohistopathological changes in rats on days 3 and 7 after injection, suggesting that (S)-(+)-Ketoprofen should not be intrathecally administered.ResumoJustificativa e objetivosA administração intratecal de anti-inflamatórios não esteroides é mais eficaz no tratamento da dor pós-operatória. A Anti-inflamatórios não esteroides, como o (S)-(+)-cetoprofeno, pode ser eficaz em doses intratecais inferiores às parenterais; a segurança pré-clínica relativa à possível neurotoxicidade associada ao (S)-(+)-cetoprofeno intratecal não foi avaliada. Neste estudo avaliamos a neurotoxicidade do (S)-(+)-cetoprofeno administrado por via intratecal em ratos.MétodosConduzimos um estudo experimental randomizado e controlado por placebo em ratos Sprague-Dawley (250g–300 g) com idades entre 12 e 16 semanas. Eles foram randomicamente divididos em dois grupos de tratamento [100 e 800 μg de (S)-(+)-cetoprofeno] e um de controle (água estéril). Cateteres intratecais foram colocados através do espaço atlantoaxial nos ratos anestesiados. Testes de pinça, avaliações da função motora e exames histopatológicos da medula espinhal e das raízes nervosas foram realizados nos dias 3, 7 e 21 do estudo. Os cortes da medula espinhal foram ...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research

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Cesarean section (CS) is one of the most common surgical procedures and postoperative pain control is an important aspect of postoperative management.1 Generally, spinal anesthesia is performed for the peri-operative management of CS. Spinal anesthesia with opioids has gained popularity for postoperative pain relief because it reportedly results in improved analgesia, and ultrasound-guided nerve blocks have also been performed as part of multimodal analgesia after CS.2
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
In this study, effects of lidocaine on the suppressors of cytokine-signaling protein 3 (SOCS3) in microglia are investigated in chronic constriction injury (CCI) rat model and lipopolysaccharide (LPS)-stimulated BV-2 cells. It was shown that intrathecal injection of lidocaine substantially alleviated CCI-induced neuropathic pain, as reflected by the decreased thermal latency and mechanical threshold. Lidocaine reduced the CCI-evoked spinal injury and cell apoptosis. CCI induced an significant increase of IBA1+ microglia accompanied by the increase of inflammatory cytokines IL-6 and IL-1β, which were suppressed after l...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
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Source: Journal of Neurosurgical Anesthesiology - Category: Anesthesiology Tags: Departments Source Type: research
We report a case of a parturient with intense central poststroke pain after an ischemic cerebrovascular incident at 15 weeks of gestation, attributed to cerebral venous thrombosis. After a multidisciplinary team consultation, she was scheduled for cesarean delivery at 35 weeks of gestation, under combined spinal-epidural anesthesia. Due to severe left-sided neurological deficits and ipsilateral intense neuropathic pain, the neuraxial technique was successfully performed using the paramedian approach.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
In this report, we present the long-term functional and radiological outcomes following nonoperative treatment of such a fracture in a 5-year-old female. The patient was referred to our tertiary centre with radiological progression of angulation from 10° to 35° within 5 weeks of the injury, despite wearing a rigid collar. She had no neurological compromise. Although we examined the fracture under general anaesthetic, and subsequently applied halo traction, there was no effect on alignment. The halo device was removed after 11 days and a rigid collar was fitted again. The patient had no pain or neurological symptoms...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: SPINE Source Type: research
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; &AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regio...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
One of the stranger annals of pain management involved “Eclectric Oil.” Although advertisements for this nostrum appeared as early as 1858, the name of New York’s Dr. S. N. Thomas (upper left andright) was associated with the oil by 1876. Americans ’ fascination with electricity and their romance with back-to-nature versions of medical practice resulted in a portmanteau of “electric” + “eclectic,” yielding “eclectric.” Eclectric Oil was an eclectic combination of alcohol, chloroform, camphor, and balsam fir with the tinctures of opium, guaiac, and catechu, as well...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
You're reading Options to Opioids: How to Manage Chronic Pain Without Prescribing Pain-Killers, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. While there is considerable debate as to how much blame doctors should be assigned for the ongoing opioid crisis, there is little doubt they can do something to curtail it -- that instead of prescribing drugs that have been found to be highly addictive they can resort to alternate forms of pain management. Doctors’ prescription of powerful painkillers like OxyContin is frequ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness addiction health and wellness opioids self improvement Source Type: blogs
Alcyone Lifesciences is a medical technology company based out of Lowell, MA, which specializes in central nervous system (CNS) drug delivery platforms for targeted infusions of the brain or spinal cord. Their Thecaflex DRx System was recently awarde...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Neurosurgery Pain Management Psychiatry Source Type: blogs
AbstractThe sacroiliac joint (SIJ) is a possible source of persistent or new onset pain after lumbar or lumbosacral fusion. The aim of this paper is to systematically review and analyze the available literature related to the incidence, diagnosis and management of sacroiliitis after spinal arthrodesis. The authors independently screened the titles and abstracts of all articles identified concerning sacroiliac joint pain after lumbar or lumbosacral fusion, to assess their suitability to the research focus. The average incidence of sacroiliitis after lumbar or lumbosacral arthrodesis was found to be 37  ±&thins...
Source: Musculoskeletal Surgery - Category: Orthopaedics Source Type: research
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