HCBP6 Is Involved in the Development of Hepatic Steatosis Induced by High-Fat Diet and CCL4 in Rats.

HCBP6 Is Involved in the Development of Hepatic Steatosis Induced by High-Fat Diet and CCL4 in Rats. Ann Hepatol. 2018 May - Jun;17(3):511-518 Authors: Zheng YP, Zhong XY, Huang YS, Zheng CB Abstract Introduction and alm. Hepatitis C virus core-binding protein 6 (HCBP6) was previously found to be an hepatitis C virus corebinding protein, its biological function remains unclear. Our research aims to investigate the role of HCBP6 in the development of hepatic steatosis induced by high-fat diet and carbon tetrachloride (CCL4) in rats. MATERIAL AND METHODS: Eighteen Wistar rats were randomly allocated into 3 groups: control group, model group 1, and model group 2. The control group was treated with a standard diet for 5 weeks. Model groups were treated with high-fat diet and CCL4 injection twice a week for 3 weeks in Group 1 and 5 weeks in Group 2, respectively. After the intervention, hepatic steatosis was observed by histological staining with hematoxylin and eosin (H&E) and Oil Red O staining. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and triglycerides (TGs) were measured. The TG content in liver homogenates was evaluated. Expressions of HCBP6 and SREBP-1c were determined by immunofluorescence, quantitative real-time PCR, and Western blot analysis. RESULTS: Hepatic steatosis was successfully induced in model groups. ALT, AST, TC, and TGs elevated in model groups compared with those in ...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Related Links:

MicroRNA-122 (miR-122) is highly expressed in hepatocytes, where it plays an important role in regulating cholesterol and fatty acid metabolism, and it is also a host factor required for hepatitis C virus replication. miR-122 is selectively stabilized by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2 (also known as PAPD4 or TENT2). However, it is unclear how GLD-2 specifically stabilizes miR-122. Here, we show that QKI7 KH domain-containing RNA binding (QKI-7), one of three isoforms of the QKI proteins, which are members of the signal transduction and activation of RNA (STAR) family of RNA-bindin...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: RNA Source Type: research
o Binder Chronic Hepatitis C virus (HCV) infection still constitutes a major global health problem with almost half a million deaths per year. To date, the human hepatoma cell line Huh7 and its derivatives is the only cell line that robustly replicates HCV. However, even different subclones and passages of this single cell line exhibit tremendous differences in HCV replication efficiency. By comparative gene expression profiling using a multi-pronged correlation analysis across eight different Huh7 variants, we identified 34 candidate host factors possibly affecting HCV permissiveness. For seven of the candidates, we c...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionBupleuri Radix/Curcumae Radix medicine pair may have an effect on the procedure of programmed death and apoptosis and lipid metabolism. PIK3CG, BCL2, CASP3, MMP1 and CASP8 may play a key role in the treatment of hepatitis C. The two medicines may work on those targets and have an effect on hepatitis C.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
In conclusion, we studied the incidence of OCI in Iranian patients with hemophilia for the first time. Our results demonstrated that unfavorable genotypes of IFNL3 SNPs and IFNL4 ss469415590 have a strong relationship with OCI positivity. It seems that the host immune response plays a vital role in OCI positivity. PMID: 31838260 [PubMed - as supplied by publisher]
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Canadian researchers found giving uninfected recipients a combination of antiviral and cholesterol-lowering drugs prevented them from contracting the virus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele. World J Gastroenterol. 2019 Oct 14;25(38):5826-5837 Authors: Gonzalez-Aldaco K, Roman S, Torres-Valadez R, Ojeda-Granados C, Torres-Reyes LA, Panduro A Abstract BACKGROUND: Cholesterol is related to improvements in the rate of sustained virological response and a robust immune response against the hepatitis C virus (HCV). APOE gene polymorphisms regulate cholesterol levels modifying the course of the HCV infection. The relationship between cholesterol, AP...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Gastric cancer incidence and death half as likely over 22 years after short-term H. pylori treatment Related items fromOnMedica Antivirals cut liver cancer risk after hepatitis C Statins might not cut colorectal cancer risk after all Antibiotics, H2RAs and PPIs linked to child obesity Long-term use of PPIs linked to doubling in stomach cancer risk Taking aspirin with a PPI reduces risk of oesophageal cancer
Source: OnMedica Latest News - Category: UK Health Source Type: news
Familial hypercholesterolemia type IIA (FH) is due to mutations in the low-density lipoprotein receptor (LDLR) resulting in elevated levels of low-density lipoprotein cholesterol (LDL-c) in plasma and in prema...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Conclusion: This study clearly shows that the non-host humoral milieu such as mouse, and DMEM decreases the RNA level and surface antigenicity, clinically implying the decremental infectivity of HCV virions. This is the frst note to tune HCV viability via conditioning only host humoral milieu free of genetic approach.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
This study elicited the preferences of CHC patients for treatment attributes of new DAAs.MethodsAn online discrete choice experiment survey was designed to collect data from adult CHC patients in the USA, UK, France, Germany, Spain, and Italy. Patients were asked to choose from alternative hypothetical DAA options, defined by differing levels of nine attributes [i.e., treatment duration, tablet count and packaging, cure rate, required office visits when on treatment, modifications to statins or to proton pump inhibitors (PPIs), and risks of diarrhea, headache and nausea]. Logistic regression was used to assess preference f...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
More News: Cholesterol | Diets | Gastroenterology | Hepatitis | Hepatitis C | High Fat | Liver | Nutrition | Urology & Nephrology