Population Scale Retrospective Analysis Reveals Potential Risk of Cholestasis in Pregnant Women Taking Omeprazole, Lansoprazole, and Amoxicillin

AbstractIn nearly 50% of patients with drug-induced liver injury, the bile flow is impaired known as cholestasis. Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease that happens in pregnancy. Some of the clinical symptoms include pruritus, dark urine, and abnormal liver function tests. A rise of serum bile acids is the most accurate diagnostic evidence. ICP may lead to premature birth, fetal distress, and even postpartum hemorrhage or stillbirth in some severe cases. Higher bile acid levels (>  40 μmol/L) are associated with higher rates of adverse fetal outcomes. Due to the multifactorial nature of ICP, its etiology is still not fully understood. Therefore, the current treatments of ICP are limited to control symptoms and protect fetuses. Among various causing factors, drug exposure during pregnancy is one common factor, and it can be prevented if we know drugs with increasing risk of cholestasis. Here we analyzed over 9.5 million FDA adverse effect reports to identify drugs with increasing risks of cholestasis as an adverse effect. Patients treated for cholestasis or liver dis eases were removed. The odds ratio analysis reveals that lansoprazole (LSPZ), omeprazole (OMPZ) and amoxicillin (AMXC) are associated with an increased risk of cholestasis. LSPZ is associated with increased reported cholestasis by a factor of 2.32 (OR with 95% confidence interval [2.21, 2.43]). OMPZ is associated with increased reported cholestasis by a fact...
Source: Interdisciplinary Sciences, Computational Life Sciences - Category: Bioinformatics Source Type: research

Related Links:

The purpose of this video is to demonstrate the technique of laparoscopic management of a cornual ectopic pregnancy.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Video Cafe Source Type: research
This video demonstrates a four step strategy for robot-assisted (RA) abdominal cerclage placement prior to pregnancy.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Video Presentation Source Type: research
Conclusions: The common prevalence of smoking among pregnant women with HIV and its association with adverse outcomes indicates that smoking cessation programs in this population may have a significant impact on neonatal and maternal health. PMID: 32100603 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
AbstractNative circulating oxytocin (OT) levels in non ‐pregnant/non‐lactating/non‐medicated humans are very low (≤8 pg/mL). The lower limit of detection (LLOD) of our previous liquid chromatography mass spectrometry (LC‐MS) method (10‐25 pg/mL) precluded their quantification in serum and urine. Thus, we sought to improve the LC‐MS sensiti vity of OT measurements in these matrices by hydrophobic tagging and solid phase extraction (SPE). In the former approach, OT was reduced then alkylated with N‐alkyl acetamide (C12, C14, C16, and C18) tags or derivatized using sulfonyl chloride‐based reagents. In the l...
Source: Drug Testing and Analysis - Category: Drugs & Pharmacology Authors: Tags: SHORT COMMUNICATION Source Type: research
Purpose of review To review recent evidence on the capacity of vitamin D to prevent atopic disease, focussing on food allergy and asthma, and potential underlying mechanisms. Recent findings The incidence of allergic disease continues to increase worldwide. Vitamin D status is influenced by sun exposure and dietary intake. Vitamin D deficiency is linked to an increased incidence of allergic disease and asthma. These associations are generally strongest in early life. The capacity of vitamin D to enhance antimicrobial pathways, promote peripheral immunological tolerance and maintain mucosal barrier integrity may underl...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research
This study aimed to explore the effect of antidepressant treatment on the HPA axis, changes in depression score, and serum levels of TNF- α in depressed infertile women. Methods In this randomized controlled trial research, 60 infertile women who had undergone in vitro fertilization (IVF) treatment with depression scores between 16-47 were divided into two groups. The intervention group with fluoxetine capsule was under treatment for two months before the embryo transfer, while the control group was given placebo. Depression score, serum levels of tumor necrosis factor alpha (TNF- α ) as well as cortisol hormon...
Source: Revista de Psiquiatria Clinica - Category: Psychiatry Source Type: research
Authors: Chen F, Wang H, Xiao J Abstract End-stage liver disease is one of the leading causes of death around the world. Since insufficient sources of transplantable liver and possible immune rejection severely hinder the wide application of conventional liver transplantation therapy, artificial three-dimensional (3D) liver culture and assembly from stem cells have become a new hope for patients with end-stage liver diseases, such as cirrhosis and liver cancer. However, the induced differentiation of single-layer or 3D-structured hepatocytes from stem cells cannot physiologically support essential liver functions d...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
CONCLUSIONSPregnancy resource centers play a role in meeting the acute material and social needs of low ‐income pregnant women. However, the constraints on the resources the centers offer mean that this support cannot be part of a reliable system of care. Advocates and policymakers should take a nuanced approach to regulating these centers and consider the reasons women visit them, especially low‐ income women.
Source: Perspectives on Sexual and Reproductive Health - Category: Sexual Medicine Authors: Tags: ARTICLE Source Type: research
Conclusions: This study provided the first prospective evidence of a positive association between prolactin levels in early pregnancy and GDM risk.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Much more than just a cosmetic issue, obesity is associated with type 2 diabetes, heart disease, high blood pressure, stroke, fatty liver disease, sleep apnea, arthritis, gallbladder disease and more, according to the U.S. National Institute for Diabetes and Digestive and Kidney Diseases.
Source: WebMD Health - Category: Consumer Health News Source Type: news
More News: Amoxicillin | Bile | Bioinformatics | Cholestasis | Lansoprazole | Liver | Liver Disease | Obstetric Cholestasis | Omeprazole | Pregnancy | Premature Birth | Prevacid | Prilosec | Urology & Nephrology | Women