Amygdala rapid kindling impairs breathing in response to chemoreflex activation.

Amygdala rapid kindling impairs breathing in response to chemoreflex activation. Brain Res. 2019 May 13;: Authors: Totola LT, Malheiros-Lima MR, Delfino-Pereira P, Vecchio FD, Souza FC, Takakura AC, Garcia-Cairasco N, Moreira TS Abstract Temporal lobe epilepsy is often accompanied by behavioral, electroencephalographic and autonomic abnormalities. Amygdala kindling has been used as an experimental model to study epileptogenesis. Although amygdala kindling has been extensively investigated in the context of its clinical relevance to the epilepsies, potential associated respiratory alterations are not well known. Here, our main objective was to better investigate the mechanisms involved in respiratory physiology impairment in the amygdala rapid kindling (ARK) model of epileptogenesis. Male Wistar rats with electrodes implanted into the amygdaloid complex were used. After recovery from surgery, the rats were subjected to electrical stimulation of basolateral amygdala for 2 consecutive days (10 stimuli/day). The ventilatory parameters were evaluated by whole body plethysmography. Thereafter, animals were also exposed to hypercapnia (7% CO2) for 3 h to evaluate fos protein expression in several nuclei involved in respiratory control. We observed a significant reduction in ventilation during the ictal phase elicited by ARK. We also found that 10 days after ARK, baseline ventilation as well as the hypercapnia ventilatory response (7% CO2) w...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research