MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability.

In conclusion, miR-4319 dampened YAP expression to mitigate the tumorigenesis of NSCLC through inhibiting LIN28-mediated RFX5 stability, which offered an insight into the molecular mechanism underlying miR-4319 in NSCLC development. PMID: 31096145 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31096145?dopt=Abstract

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 12, 2019 Category: Drugs & Pharmacology Authors: Yang Y, Li H, Liu Y, Chi C, Ni J, Lin X Tags: Biomed Pharmacother Source Type: research