An increased mortality risk is associated with abnormal iron status in diabetic and non-diabetic Veterans with pre-dialysis chronic kidney disease

Iron parameters have not been well characterized in pre-dialysis patients with chronic kidney disease, and it remains unclear if abnormal iron balance is associated with increased mortality. Therefore, we performed a historical cohort study using data from the Veterans Affairs Corporate Data Warehouse to evaluate the relationship between iron status and mortality. We identified a pre-dialysis chronic kidney disease cohort with at least one set of iron indices between 2006-2015. The cohort was divided into four iron groups based on the joint quartiles of serum transferrin saturation (percent) and ferritin concentration (ng/mL): Reference (16-28%, 55-205 ng/mL), Low Iron (0.4-16%, 0.4-55 ng/mL), High Iron (28-99.6%, 205-4941 ng/mL), and Function Iron Deficiency (0.8-16%, 109-2783 ng/mL).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research