Centers Without Walls for Collaborative Research in the Epilepsies: Functional Evaluation of Human Genetic Variants (U54 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-19-019 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage cooperative agreement (U54) applications from multidisciplinary groups of investigators to accelerate the rate of progress in determining the functional, pharmacological, neuronal network and whole animal consequences of genetic variants discovered in patients with various types of epilepsy and to develop strategies for establishing diagnostic criteria and identifying potential targets for intervention.
ABSTRACT Objective To analyze the risk factors and prognosis related to early post-traumatic epilepsy (EPTE). Methods One hundred and eighty-six patients with traumatic brain injury were enrolled. Their full clinical data were collected. Single factor analysis and logistic regression analysis of risk factors related to EPTE were performed. The prognosis of patients was determined. Results Single factor analysis showed that there were significant differences of age (p = 0.011), epilepsy history (p
This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.RESUMO A vortioxetina é um agente antidepressivo multimodal que modula os receptores 5HT e inibe o transportador de serotonina. Está indicada, principalmente nos casos de transtorno depressivo maior (TDM), relacionado à disfunção cognitiva. Existem muitos estudos que investigam os efeitos dos antidepressivos no limi ar convulsivo e na atividade epiléptica de cu...
Glucose transporter-1 (GLUT1)/SLC2A1 is expressed at the highest levels in brain capillaries, astroglia, and erythrocytes. GLUT1-deficiency syndrome is a neurological disorder resulting primarily from aberrant glucose transport into the brain. Clinically, it is classified as GLUT1-deficiency syndrome with epilepsy and without epilepsy. The phenotypic spectrum of GLUT1- deficiency syndrome expanded over last two decades, encompassing a varying combination of epilepsies (absence, atypical absence, myoclonic, myoclonic-astatic, refractory generalized epilepsy, intractable infantile epilepsy etc.), movement disorders (paroxysm...
ConclusionsThe proposed method successfully reduces computation time of an IED detection system. Therefore, it is beneficial in speeding up IED detection especially when utilizing large EEG datasets.Graphical abstract
Authors: Nishitani A, Yoshihara T, Tanaka M, Kuwamura M, Asano M, Tsubota Y, Kuramoto T Abstract Hyperpolarization-activated cyclic nucleotide-gated 1 (HCN1) channels contribute to spontaneous rhythmic activity in different tissues, including the heart and brain. Deficiency in HCN1 function is associated with sick sinus syndrome in mice and epilepsy in humans. We recently developed Hcn1-deficient rats and found that they exhibit absence epilepsy. While rearing Hcn1-deficient rats, we noticed loose muscle tension and abnormal gait. We therefore evaluated the muscle strength and motor functions of Hcn1-deficient rats...
Publication date: Available online 12 July 2019Source: Epilepsy &BehaviorAuthor(s): Massimiliano Beghi, Cesare Maria Cornaggia, Ettore Beghi, William Curt LaFrance
ConclusionTPPU treatment after SE attenuates SRS and epilepsy-associated depressive behaviours in the LiCl-pilocarpine induced post-SE rat model, and it also exerts anti-inflammatory effects in the brain. Our findings suggest a new therapeutic approach for epilepsy and its comorbidities, especially depression.
ConclusionManagement of SE in pregnancy is influenced by etiology of SE and duration of pregnancy. It carries a good prognosis if detected early and treated appropriately. Large-scale multicentric studies are warranted for formulating definite guidelines for management of SE in pregnancy.This article is part of the Special Issue “Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures”.
This article is part of the Special Issue “Seizures &Stroke”.