F26. Exploring Post-Zygotic Variants in Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder (OCD) is a debilitating neuropsychiatric disorder that is known to be moderately heritable but has poorly understood pathogenesis, limiting development of novel pharmacologic treatments. Previous studies suggest a significant contribution to OCD risk from de novo germline variants, which arise spontaneously in the parental germ cells or zygote. Recent studies of autism spectrum disorder and intellectual disability suggest a risk contribution from post-zygotic variants (PZVs) arising de novo in multicellular stages of embryogenesis, suggesting these mosaic variants can be used to examine the genetic underpinnings of other neuropsychiatric disorders such as OCD.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research