Delayed primary diagnosis of LEOPARD syndrome type 1

To the Editor: LEOPARD syndrome (LS) is a rare autosomal dominant genodermatosis. It is characterized by multiple Lentigines, Electrocardiographic abnormalities, Ocular hypertelorism, Pulmonary valve stenosis, Abnormal genitals, Retarded growth, and Deafness. Like neurofibromatosis type 1, Noonan syndrome, Costello syndrome, and cardiofaciocutaneous syndrome, it belongs to the group of neurocardiofaciocutaneous diseases. Zeisler and Becker reported the first case of LS in 1936, and later the acronym of the syndrome was coined because of the multiple lentigines that resemble the fur pattern of a leopard. The acronym has been widely used ever since.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD Online Source Type: research