Controlled release Ibu-cryobarriers for the prevention of post-operative adhesions: In-vitro/in-vivo comparative study

Publication date: 30 June 2019Source: International Journal of Pharmaceutics, Volume 565Author(s): Noha S. El-Salamouni, Mennatallah A. Gowayed, Gihan S. LabibAbstractPost-operative adhesion is a common cause of several complications including intestinal obstruction, chronic pelvic pain and/or infertility. Adhesions are fibrous bands that result from the inflammatory reactions due to peritoneum damage. The current study focused on designing an effective anti-inflammatory loaded barrier for the prevention of post-operative adhesions. The proposed method is based on the use of polyvinyl alcohol (PVA), cryobarrier loaded with Ibuprofen (Ibu). Anti-adhesive Ibu-cryobarriers were prepared in different forms, and subjected to in-vitro evaluation comprising; drug release rate, maximum swelling index, morphological examination using scanning electron microscope (SEM), fourier-transform infrared spectroscopy (FTIR) and mechanical properties. Optimized cryobarriers were further investigated for their in-vivo effectiveness in preventing post-operative adhesions in female Sprague-Dawley rats. All formulations showed appropriate physical and morphological characteristics, in-vitro controlled sustained drug release profiles during a period of seven days with acceptable maximum swelling index. Invivo, all cryobarriers were equivalent to each other concerning serum or tissue parameter. However, morphological and histopathological evaluations revealed that both xerocryogel and lyophilized cry...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: January 2020Source: Biometric Technology Today, Volume 2020, Issue 1Author(s): US NIST (the National Institute of Standards and Technology) has released three new biometric databases – featuring fingerprints, facial photographs and iris scans – designed to help researchers reduce the error rates of biometric systems.
Source: Biometric Technology Today - Category: Information Technology Source Type: research
Publication date: January 2020Source: Biometric Technology Today, Volume 2020, Issue 1Author(s): Jason TooleyThe use of biometrics by police forces has rarely been out of the headlines over the past year. As with many emerging technologies, it has hit significant hurdles. Recently in an unprecedented move, the UK's Information Commissioner's Office (ICO) – the government body responsible for GDPR and data privacy enforcement – launched an independent investigation into the use of facial recognition at London's King's Cross train station, after it was revealed that the general public were having their faces scan...
Source: Biometric Technology Today - Category: Information Technology Source Type: research
Ureaplasma urealyticum (uu) is one of the most common agents of urogenital infections and is associated with complications such as infertility, spontaneous abortion and other sexually transmitted diseases. Here, a DNA sensor based on oligonucleotide target-specific gold nanoparticles (AuNPs) was developed, in which the dispersed and aggregated states of oligonucleotide-functionalised AuNPs were optimised for the colorimetric detection of a polymerase chain reaction (PCR) amplicon of U. urealyticum DNA. A non-cross-linking approach utilising a single Au-nanoprobe specific of the urease gene was utilised and the effect of a ...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
In this research, the hydrothermal method was used for synthesising cellulose acetate (CA) templated nanorods like CuS fibres using vegetable extract (Brassica oleracea var. italica). These extracts act as a reducing agent in the presence of CA. Surprisingly, when the same reaction was carried out in the absence of CA and broccoli extract, structural morphology disappeared and was found as agglomerated. In the presence of cellulose templated extract mediated CuS has revealed as nanorods like fibres and was confirmed by field emission scanning electron microscope analysis. Their crystallinity property of CuS nanoparticles (...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
To sustained release of an anticancer drug, oxaliplatin (OX), a non-toxic and biocompatible nanocarrier based on bovine serum albumin (BSA) were synthesised by desolvation method and characterised using Fourier-transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM) and dynamic light scattering. The results showed that the BSA nanoparticles (BSANPs) with a mean magnitude of 187.9 ± 1.2 nm have spherical morphology with a smooth surface and a uniform distribution. Furthermore, OX was loaded onto the BSANPs and the loading was confirmed...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
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Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Conclusion: there is no increased risk of doing the lymph node dissection early on.   Dr. Eggener-CON   Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nod...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
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