Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy.

CONCLUSIONS: By applying a novel systems pharmacology data analysis framework, three commonly used ARTs (ritonavir, nelfinavir and saquinavir) were found altering the activity of a regulatory gene network (AR-RGN) promoting foam cell formation and risk of CAD. Targeting AR-RGN or its top key driver PQBP may help reduce CAD side effects of these ART drugs.
PMID: 31059280 [PubMed - as supplied by publisher]

Source: Topics in HIV Medicine - May 5, 2019 Category: Infectious Diseases Authors: Frades I, Readhead B, Amadori L, Koplev S, Talukdar HA, Crane HM, Crane PK, Kovacic JC, Dudley JT, Giannarelli C, Björkegren JLM, Peter I Tags: Circ Genom Precis Med Source Type: research