Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics

Publication date: Available online 6 May 2019Source: Trends in Pharmacological SciencesAuthor(s): Ofer Yizhar, J. Simon WiegertChemogenetic techniques allow selective manipulation of neurons by activating engineered actuator proteins with otherwise inert effector molecules. A recent study (Magnus et al. Science 2019;364:eaav5282) describes the coevolution of highly potent actuator–effector pairs based on a clinically approved antismoking drug. These tools allow selective excitation or inhibition of neurons in the living brain with high specificity and no detectable side-effects.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research