Synergistic effects of combined vaccination with BCG and influenza vaccines on spatial cognition and hippocampal plasticity in rats.

Synergistic effects of combined vaccination with BCG and influenza vaccines on spatial cognition and hippocampal plasticity in rats.
Brain Res Bull. 2019 Apr 30;:
Authors: Li Q, Xuan A, Qi F, Yang J, Zou J, Yao Z
Abstract
Previous study has demonstrated the neurobeneficial role of BCG and influenza vaccines. Based on this, our study concentrated on the synergistic effects on development of central nervous system by combined vaccination with BCG and influenza vaccines in rats. Our results displayed that pups combinedly vaccinated with BCG and influenza vaccines showed a significant enhance in spatial cognition, induction of LTP, hippocampal neurogenesis and morphology of dendritic spines compared with pups vaccinated with BCG solely. Furthermore, combined vaccination with BCG and influenza vaccines showed higher expression of BDNF, IGF-1, IL-4, IFN-γ and lower IL-1β, TNF-α and IL-6 than BCG. Taken together, combined vaccination with BCG and influenza vaccines presented synergistic effects on spatial cognition and hippocampal plasticity in rats.
PMID: 31051226 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - April 29, 2019 Category: Neurology Authors: Li Q, Xuan A, Qi F, Yang J, Zou J, Yao Z Tags: Brain Res Bull Source Type: research