Long non-coding RNA polymorphisms and prediction of response to chemotherapy based on irinotecan in patients with metastatic colorectal cancer.

CONCLUSIONS: CT genotype of rs3200401 MALAT1 polymorphism could serve as a toxicity biomarker. Carriers of the G allele of the rs4759314 HOTAIR are more likely to be carriers of KRAS mutations too. However, further studies in larger patient populations are required. PMID: 31045514 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31045514?dopt=Abstract

Source: Cancer Biomarkers : Section A of Disease Markers - April 18, 2019 Category: Cancer & Oncology Authors: Lampropoulou DI, Aravantinos G, Katifelis H, Lazaris F, Laschos K, Theodosopoulos T, Papadimitriou C, Gazouli M Tags: Cancer Biomark Source Type: research