Mayo Clinic goes off-label to treat severe bleeding disorder

For people with a rare bleeding disorder called "hereditary hemorrhagic telangiectasia," or HHT, simple issues such as a nosebleed can be life-threatening. The disease has no cure. But Dr. Vivek Iyer, a Mayo Clinic pulmonary and critical care physician, found that a drug commonly used for cancer can stop the bleeding and restore quality of [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

Related Links:

AM Abstract Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. Definition of key characteristics relevant for effective and specific tumor rejection is essential to improve current TCR-based adoptive T-cell immunotherapies. We here characterized in-depth two TCRs derived from the human leukocyte antigen (HLA)-mismatched allogeneic repertoire targeting two different myel...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Front Immunol Source Type: research
ConclusionsThe study recommend the development of a model to guide the integration of breast cancer prevention and early detection into palliative care
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Advances in nanophotonics could one day lead to new treatments for cancer, mental disorders More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298904&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Brigid K. Killelea, Emily J. Gallagher, Sheldon M. Feldman, Elisa Port, Tari King, Susan K. Boolbol, Rebeca Franco, Kezhen Fei, Derek Le Roith, Nina A. BickellAbstractIntroductionAlthough breast cancer incidence is higher among white women, black women are more likely to have aggressive tumors with less favorable histology, and to have a worse prognosis. Obesity and alcohol consumption have been identified as two modifiable risk factors for breast cancer, while physical activity may offer protection. Little however is known abo...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Laura H. Rosenberger, Samantha M. Thomas, Jennifer K. Plichta, Oluwadamilola M. Fayanju, Terry Hyslop, Rachel A. Greenup, E. Shelley HwangAbstractBackgroundSentinel lymph node biopsy has supplanted axillary lymph node dissection (ALND) in clinically node-negative breast cancer and select node-positive disease. We hypothesized a decreasing rate of both ALND and resident exposure over time.MethodsWe identified women with clinical Stage I-III breast cancer in the National Cancer Data Base (2004-2014). Adjusted multivariate logisti...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAmong breast cancer patients, nearly one-third exhibit clinical-pathological stage discordance. This high likelihood of discordance is important to consider for counseling and treatment planning.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
This study assessed the effectiveness and safety of percutaneous mechanical thrombectomy and catheter-directed thrombolysis combined with stent placement in the management of iliac vein compression syndrome with acute iliofemoral deep venous thrombosis (DVT).MethodsFrom December 2014 to April 2016, there were 46 patients with DVT who underwent percutaneous mechanical thrombectomy and catheter-directed thrombolysis and stenting for acute proximal DVT with computed tomography-verified iliofemoral stenosis. The Venous Registry Index was used for evaluating the degree of patency after pharmacomechanical thrombolysis; the preva...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
In this report, we describe two cases of large venous malformation in the lower lip that were successfully treated by percutaneous sclerotherapy followed by plastic surgery. In our two-case presentation, sclerotherapy was performed prior to plastic surgery to improve the efficiency and reduce excessive bleeding, which resulted in significantly improved appearance and physical function.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 19 July 2019Source: European Journal of Surgical OncologyAuthor(s): John Tapper, Stefan Arver, Torbjörn Holm, Matteo Bottai, Mikael Machado, Ravi Jasuja, Anna Martling, Christian BuchliAbstractAimThe aim of this study is to analyze postoperative adverse events (AE) in relation to acute primary testicular failure after radiotherapy (RT) for rectal cancer.MethodThis relation was assessed in 104 men, included in a previous prospective cohort study of men treated with surgical resection of the rectum for rectal cancer stage I-III. Postoperative AE were graded according to Clavien-Dindo (...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionExhaled breath condensate analysis combined with MS technique may become a valuable method for lung cancer screening and Dermcidin and S100A9 may serve as biomarkers for lung cancer diagnosis or prognosis.
Source: Lung - Category: Respiratory Medicine Source Type: research
More News: Bleeding | Cancer | Cancer & Oncology | Databases & Libraries | Epistaxis (Nosebleeds) | Hereditary Hemorrhagic Telangiectasia