Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response

This study provides a rationale for the genome-wide characterization of MSI intensity and mutational load to better profile responses to anti–PD-1 immunotherapy across MMR-deficient human cancers.

Source: ScienceNOW - May 1, 2019 Category: Science Authors: Mandal, R., Samstein, R. M., Lee, K.-W., Havel, J. J., Wang, H., Krishna, C., Sabio, E. Y., Makarov, V., Kuo, F., Blecua, P., Ramaswamy, A. T., Durham, J. N., Bartlett, B., Ma, X., Srivastava, R., Middha, S., Zehir, A., Hechtman, J. F., Morris, L. G., Wei Tags: Genetics, Medicine, Diseases reports Source Type: news