Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction

Publication date: Available online 30 April 2019Source: PeptidesAuthor(s): Richard J. BodnarAbstractThis review is part of a Special Issue dedicated to Opioid Addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid mediation of food intake was an example of “positive addictive” properties that provide motivational drives to maintain opioid-seeking behavior and that are not subject to the “negative addictive” properties associated with tolerance, dependence and withdrawal. Data demonstrate that opiate and opioid peptide agonists stimulate food intake through homeostatic activation of sensory, metabolic and energy-related In contrast, general, and particularly mu-selective, opioid receptor antagonists typically block these homeostatically-driven ingestive behaviors. Intake of palatable and hedonic food stimuli is inhibited by general, and particularly mu-selective, opioid receptor antagonists. The selectivity of specific opioid agonists to elicit food intake was confirmed through the use of opioid receptor antagonists and molecular knockdown (antisense) techniques incapacitating specific exons of opioid receptor genes. Further extensive evidence demonstrated that homeostatic and hedonic ingestive situations correspondingly altered the levels and expression of opioid peptides and opioid receptors. Opioid mediation of food intake was c...
Source: Peptides - Category: Biochemistry Source Type: research