Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

ConclusionsThis study suggests that exome-derived mutated HLA ligands appear to be rarely presented in HCCs,inter alia resulting from a low mutational burden as compared to other malignancies such as malignant  melanoma. Our results therefore demand widening the target scope for personalized immunotherapy beyond this limited range of mutated neoepitopes, particularly for malignancies with similar or lower mutational burden.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research