Therapeutic targeting of gastrointestinal cancer stem cells.

Therapeutic targeting of gastrointestinal cancer stem cells. Regen Med. 2019 Apr 26;: Authors: Stem J, Flickinger JC, Merlino D, Caparosa EM, Snook AE, Waldman SA Abstract Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer. PMID: 31025613 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - Category: Genetics & Stem Cells Authors: Tags: Regen Med Source Type: research