Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob / ob mice

AbstractThe antidiabetic effects of a hot water extract of the stems ofSalacia chinensis (SCE) were evaluated in vivo inob/ob mice (genetically obese hyperglycemic mice). Administration of dietary feed containing 0.20 and 0.50% of SCE for 23  days toob/ob mice significantly suppressed the elevation of both blood glucose and HbA1c levels, without significantly changing body weight and food intake. To characterize the antidiabetic effects of the thiosugar sulfonium constituent neokotalanol (1), which has potentα-glucosidase inhibitory activity, we performed a similar in vivo study. HbA1c levels were significantly suppressed inob/ob mice after the administration of dietary feed containing 0.0003% of neokotalanol (1) for 20  days. These results indicate that SCE and neokotalanol (1) are potential leads for the development of novel antidiabetic agents.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research