Combination therapy of sofosbuvir and ribavirin fails to clear chronic hepatitis E infection in a multivisceral transplanted patient

Infections with zoonotic hepatitis E virus (HEV) have been increasingly reported in industrialized countries. Three months of detectable virus replication define chronic HEV infection,1 which may rapidly progress to severe liver disease.2 Patients under immunosuppression following solid organ transplantation represent the largest group at risk of chronic HEV infection. However, there have been anecdotal reports about chronic HEV infection in patients receiving immunosuppressive medication regimens including rituximab or inhibitors of TNF- α.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research