Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial [Medical Sciences]

There are adaptive T-cell and antibody autoimmune responses to myelin-derived peptides in multiple sclerosis (MS) and to aquaporin-4 (AQP4) in neuromyelitis optica spectrum disorders (NMOSDs). Strategies aimed at antigen-specific tolerance to these autoantigens are thus indicated for these diseases. One approach involves induction of tolerance with engineered dendritic cells (tolDCs)...

Source: Proceedings of the National Academy of Sciences - April 22, 2019 Category: Science Authors: Irati Zubizarreta, Georgina Florez–Grau, Gemma Vila, Raquel Cabezon, Carolina Espana, Magi Andorra, Albert Saiz, Sara Llufriu, Maria Sepulveda, Nuria Sola–Valls, Elena H. Martinez–Lapiscina, Irene Pulido–Valdeolivas, Bonaventura Ca Tags: PNAS Plus Source Type: research