Scratching the skin primes the gut for allergic reactions to food, mouse study suggests

(NIH/National Institute of Allergy and Infectious Diseases) Scratching the skin triggers a series of immune responses culminating in an increased number of activated mast cells -- immune cells involved in allergic reactions -- in the small intestine, according to research conducted in mice. This newly identified skin-gut communication helps illuminate the relationship between food allergy and atopic dermatitis (a type of eczema), a disease characterized by dry, itchy skin. The NIAID-supported study was led by researchers at Boston Children's Hospital.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusion: In patients with hypertension, a 4-week treatment with firibastat, tended to decrease daytime SBP relative to placebo. Firibastat did not modify the activity of the systemic renin–angiotensin system These results have justified designing a larger, powered trial of longer duration to fully assess its safety and effectiveness. Clinical trial registration: http://www.clinicaltrials.gov. NCT02322450.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research
Conclusion: Ce6-mediated PDT might be used as a potent therapeutics for AD via restoring Th1/Th2 balance and reducing over expressed immune cells.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
ConclusionModerate-to-severe AD is associated with significant decrements of health utility in the US population. These data illustrate the heavy societal burden of moderate and severe AD and provide important insight for prioritization of resource allocation and cost-effectiveness research.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Evidence suggests that, compared with no probiotic, currently available probiotic strains probably make little or no difference in improving patient-rated eczema symptoms. Probiotics may make little or no difference in QoL for people with eczema nor in investigator-rated eczema severity score (combined with participant scoring for eczema symptoms of itch and sleep loss); for the latter, the observed effect was small and of uncertain clinical significance. Therefore, use of probiotics for the treatment of eczema is currently not evidence-based. This update found no evidence of increased adverse effects with pro...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionsSelf-reported adult-onset AD is common and has distinct phenotypes with lesional predilection for the hands and/or head/neck.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Atopic dermatitis (AD) is associated with intense itch and loss of sleep in early life and with food allergy and asthma, in later life. The early origins of AD are incompletely understood but involve a complex interplay between the skin barrier, immune dysregulation, and the cutaneous microbiome. Eczema has a close relationship with Staphylococcus aureus colonization, which is associated with flares of AD. However, it was not known whether S aureus colonization preceded eczema or eczema followed S aureus colonization.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: The Editors' choice Source Type: research
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell li...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
Publication date: Available online 13 September 2015 Source:The Lancet Author(s): Stephan Weidinger, Natalija Novak Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. Although it most often starts in infancy and affects two of ten children, it is also highly prevalent in adults. It is the leading non-fatal health burden attributable to skin diseases, inflicts a substantial psychosocial burden on patients and their relatives, and increases the risk of food allergy, asthma, allergic rhinitis, other immune-mediat...
Source: The Lancet - Category: Journals (General) Source Type: research
Conclusion: The patients' histories and findings indicate the possibility of percutaneous sensitization through occupational exposure to parvalbumin, leading to food allergy.Case Rep Dermatol 2015;7:227-232
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
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