Esterification influence in thermosensitive behavior of copolymers PNIPAm-co-PAA and PNVCL-co-PAA in magnetic nanoparticles surface

Publication date: Available online 20 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): B.E. Amantea, R.D. Piazza, J.R.V Chacon, C.C. Santos, T.P. Costa, C.O. Rocha, J.V. Brandt, D.R.M. Godoi, M. Jafelicci, R.F.C. MarquesAbstractThe ability to generate heat from magnetic nanoparticle and the response of thermosensitive polymers poly(n-isopropylacrylamide) (PNIPAm) and poly(n-vinyl caprolactam) (PNVCL) are properties that have promoted several studies in controlled drug release systems. As the lower critical solution temperatures (LCST) of PNIPAm and PNVCL are between 32-35 °C and close to the temperature of the human body these polymers are adequate for biomedical applications. The LCST could be increased by copolymerizing the thermoresponsive polymer with a monomer with greater water affinity as poly(acrylic acid) (PAA), which was studied copolymerized with PNIPAm and PNVCL in aqueous solution. Cancer treatment is possible using the ability to generate heat from magnetic nanoparticles. Magnetic hyperthermia can be combined with controlled drug release and improve the treatment. In this work iron oxide nanoparticles were surface modified with a copolymer of acrylic acid with PNIPAm or PNVCL and then modified by esterification. Infrared spectroscopy indicated the presence of the polymer in the magnetic nanoparticles and showed the bound of carboxylic groups to the magnetite surface. The temperature-time experiments showed that magn...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research