Isoderivative chromosome 17 with multiple copies of RARα–PML fusions and Tp53 deletion in a rare case of APML

We report a case of adult APML with amplification of RARα/PML fusion protein, a consequence of isoderivative 17 with duplication of normal chromosome 15 and 17 and Tp53 deletion on derivative 17. Immunophenotyping by flow cytometry, presence of pancytopenia and epistaxis helped classify the patient as APML. FISH was used for confirmation of the same and indicated involvement of additional abnormalities.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research