Semen quality is affected by HLA class I alleles together with sexually transmitted diseases

ConclusionsThe application of HLA*PRG:LA tool to the study of male infertility provided novel insights for anHLA correlation with semen quality, namely among SHV and OLI phenotypes. The discovery of anHLA ‐A*29:02/HPV crosstalk, together with former reports ofHLA alleles conferring resistance –susceptibility to diverse human pathogens, raises the hypothesis of a mechanistic link between male infertility,HLA polymorphism, and host response to STD.

Source: Andrology - April 18, 2019 Category: Urology & Nephrology Authors: P. I. Marques, J. C. Gon çalves, C. Monteiro, B. Cavadas, L. Nagirnaja, N. Barros, A. Barros, F. Carvalho, A. M. Lopes, S. Seixas Tags: Original Article Source Type: research