131 Loss of PD-L1 expression in metastatic Merkel cell carcinoma strongly correlates with a poor prognosis
Merkel cell carcinoma (MCC) is a rare, but highly malignant skin cancer. Despite its high malignancy, however, a good prognosis, including spontaneous regression, has been reported in some sporadic cases since the first report by O ’Rourke and Bell in 1986. T-cell-mediated immunity is suggested to play an important role in tumor regression, and the expression of programmed death-ligand 1 (PD-L1) in cancer cells correlates with better clinical outcomes in MCC, in contrast to other solid carcinomas, such as malignant melanoma.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: M. Nakamura, Y. Teramoto, M. Yasuda, H. Wada, T. Ozawa, Y. Umemori, D. Ogata, T. Kobayashi, M. Hata, A. Morita Tags: Carcinogenesis and Cancer Genetics Source Type: research
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