909 PPAR γ stimulation protects from cyclophosphamide-induced hair follicle cytotoxicity and bulge stem cell damage

Permanent chemotherapy-induced alopecia (pCIA) remains a major unmet medical need in clinical oncology. We hypothesized that irreversible hair loss may result from permanent destruction of hair follicle epithelial stem cells (HFeSCs) in the bulge some of which may undergo epithelial-mesenchymal transition (EMT). Here, we investigated whether this is the case by treating full length HFs ex vivo with the cyclophosphamide metabolite, 4HC, which routinely induces reversible CIA and sometimes pCIA. Given the known protective role of PPAR γ signaling in eSCs biology, we also explored whether the PPARγ modulator, NAC-GED-0507-Levo (NACGED), protects from 4HC-induced damage.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research