Changes to Gamma-Aminobutyric Acid Levels during Short-Term Epileptiform Activity in a Kainic Acid-Induced Rat Model of Status Epilepticus: A Chemical Exchange Saturation Transfer Imaging Study.

CONCLUSIONS: GABA signal changes during epileptiform activity in the rat hippocampus, as detected using CEST imaging, provided a significant contrast according to changes in metabolic activity. Our technical approach may serve as a potential supplemental option to provide biomarkers for brain disease. PMID: 30991042 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30991042?dopt=Abstract

Source: Brain Research - April 12, 2019 Category: Neurology Authors: Lee DH, Lee DW, Kwon JI, Kim ST, Woo CW, Kon Kim J, Won Kim K, Seong Lee J, Gon Choi C, Suh JY, Choi Y, Woo DC Tags: Brain Res Source Type: research