NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1 β processing during Streptococcus pneumoniae infection.

In this study, mouse peritoneal neutrophils from C57BL/6 WT and inflammasome components knockout mice were infected by S. pneumoniae in vitro. The results showed that NLRP3 inflammasome is critically involved in neutrophil IL-1β secretion, while the AIM2 and NLRC4 inflammasomes were dispensable. Moreover, the upstream kinase, JNK, modulates ASC oligomerization and consequent caspase-1 activation and IL-1β secretion. Additionally, neutrophil serine proteases also participate in IL-1β secretion by mediating ASC oligomerization and caspase-1 activation. Taken together, these findings indicated that both the NLRP3 inflammasome-related pathway and neutrophil serine protease mediate IL-1β processing upon S. pneumoniae infection. PMID: 30982580 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30982580?dopt=Abstract

Source: Biochemical and Biophysical Research communications - April 10, 2019 Category: Biochemistry Authors: Zhang T, Du H, Feng S, Wu R, Chen T, Jiang J, Peng Y, Ye C, Fang R Tags: Biochem Biophys Res Commun Source Type: research