Marijuana Users May Need More Sedation For Medical Procedures

(CNN) — People who regularly use cannabis may need two times the level of sedation required by nonusers when undergoing medical procedures, a small-scale study finds. Fentanyl, midazolam and propofol, three sedation drugs commonly used during endoscopic procedures, were compared in the research. With “continued increase in legalization and use of cannabis, the field of anesthesia and sedation needs further studies with greater depth,” wrote the authors of the study, published Monday in The Journal of the American Osteopathic Association. Wider use follows legalization Marijuana has gained popularity around the globe in recent years due, in part, to changing laws. Between 2007 and 2015, use of marijuana increased 43% in the United States, where an estimated 13.5% of adults use cannabis, according to a United Nations report. Meanwhile, cannabis use around the world was estimated to include 183 million people, or nearly 4% of the adult population, in 2015. How does increasing cannabis use affect medical care? Researchers at Community Hospital in Grand Junction, Colorado, explored one small area of medical care: sedation. They examined the medical records of 250 patients who received endoscopic procedures between January 1, 2016, and December 31, 2017 — years after the state legalized recreational marijuana in 2012. Comparing cannabis users to nonusers, they found that patients who reported smoking or using edibles on a daily or weekly basis required 14% m...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Marijuana Source Type: news

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Conditions:   Colo-rectal Cancer;   Colon Adenoma;   ADR Interventions:   Procedure: Sedation directed by an endoscopist;   Procedure: Sedation directed by an anesthesiologist Sponsor:   Serveis de Salut Integrats Baix Empordà Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was carried out in accordance with the recommendations of the Case Western Reserve University IACUC committee. The protocol was approved by the Case Western Reserve University IACUC committee. Author Contributions LRD and DW helped design research studies, analyze data and write the manuscript. ZL, RL, and ND conducted experiments, acquired and analyzed data, and assisted with manuscript preparation. LDM conducted experiments and analyzed data. FC assisted with research design. Funding This work was supported by the NIH P30CA043703, K1CA113838, and R01DK081395. Conflict of Interest Statement The authors de...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: The results of this study indicated that thoracic EA in patients with laparoscopic cholecystectomy has significant effects on factors such as SBP and DBP and arterial blood oxygen saturation. Furthermore, EA has fewer complications than GA, and it is the preferable approach. PMID: 30820428 [PubMed]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Adv Biomed Res Source Type: research
CONCLUSIONS: In general, patients undergoing colonoscopy have a high response rate to questionnaires about MAEs. MAEs after colonoscopy are commonly seen. High age and score of American Society of Anesthesiologists (ASA) classification, female gender and duration of procedure seem to be associated with a higher risk of MAEs, whereas adequate sedation seems to decreases the risk. MAEs after colonoscopy seems to be underreported in the current literature and the existing evidence is based on inhomogeneous reports. In the current study, it was not possible to conduct a meta-analysis. There is a need for larger scale studies a...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Condition:   Anesthesia Interventions:   Drug: Propofol;   Drug: Sevoflurane Sponsor:   Centro Medico Docente la Trinidad Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Colonoscopy;   Anesthesia Interventions:   Drug: Midazolam;   Drug: Fentanyl;   Drug: Propofol Sponsor:   Federal University of Minas Gerais Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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