Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases

ConclusionsWe identified a strong association between breast cancer subtype and intracranial recurrence patterns after brain-directed radiation, particularly local progression for HER2+ and distant progression for TNBC patients. If validated, the poorer local control in HER2+ brain metastases may support evaluation of novel local therapy-based approaches, while the increased distant recurrence in TNBC suggests the need for improved systemic therapy and earlier utilization of WBRT.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research