Advances in phytochemical delivery systems for improved anticancer activity.

Advances in phytochemical delivery systems for improved anticancer activity.
Biotechnol Adv. 2019 Apr 09;:
Authors: Lagoa R, Silva J, Rodrigues JR, Bishayee A
Abstract
Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented. Current limitations, challenges and future research directions are also discussed.
PMID: 30978386 [PubMed - as supplied by publisher]

Source: Biotechnology Advances - April 8, 2019 Category: Biotechnology Authors: Lagoa R, Silva J, Rodrigues JR, Bishayee A Tags: Biotechnol Adv Source Type: research