HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.

CONCLUSION: Mutations in HDAC4 disrupt the deacetylation of FoxO1, subsequently decrease the β-cell function including insulin secretion, resulting in diabetes.
PMID: 30968599 [PubMed - as supplied by publisher]

Source: Molecular Medicine - April 8, 2019 Category: Molecular Biology Authors: Gong M, Yu Y, Liang L, Vuralli D, Froehler S, Kuehnen P, Du Bois P, Zhang J, Cao A, Liu Y, Hussain K, Fielitz J, Jia S, Chen W, Raile K Tags: Mol Genet Genomic Med Source Type: research