Selective sexual dimorphism in musculoskeletal ‐cardiopulmonary pathologies and mortality in the TNF‐transgenic mouse model of rheumatoid arthritis

ConclusionsWe find that TNF selectively drives early onset arthritis and cardiopulmonary pathologies in females. These results in the Tg3647 mouse identify it as a suitable model to better understand the mechanisms underlying sexual dimorphism and cardiopulmonary disease in the setting of inflammatory arthritis and other connective tissue diseases.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - April 9, 2019 Category: Rheumatology Authors: D Richard Bell, Emily Wu, Christopher Rudmann, Megan Forney, Claire Kaiser, Ronald Wood, Joe Chakkalakal, Nicole Paris, Alanna Klose, Guang ‐Qian Xiao, Javier Rangel‐Moreno, Maria Garcia‐Hernandez, Christopher Ritchlin, Edward Schwarz, Tags: Full Length Source Type: research