Chronic Lung Allograft Dysfunction: Definition, Diagnostic Criteria and Approaches to Treatment. A Consensus Report from the Pulmonary Council of the ISHLT

The term “chronic lung allograft dysfunction” (CLAD) has previously been introduced to identify patients with persistent pulmonary function decline after lung transplantation. Initially, CLAD was used as an umbrella term and encompassed all possible causes of pulmonary function decline, not only chronic rejection. Since chronic rejection has recently been phenotyped in bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and in a mixed phenotype, and because of different interpretations of the current CLAD definition, the Pulmonary Council of the International Society for H eart and Lung Transplantation (ISHLT) assembled a group of experts to create a robust description for the term CLAD, that would encompass its definition, etiology, phenotypes, pathology, treatment and outcome.

Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Geert M. Verleden, Allan R. Glanville, Erika D. Lease, Andrew J Fisher, Fiorella Calabrese, Paul A. Corris, Christopher R. Ensor, Jens Gottlieb, Ramsey R. Hachem, Vibha Lama, Tereza Martinu, Desley A.H. Neil, Lianne G. Singer, Greg Snell, Robin Vos Source Type: research