Change in neuron specific enolase levels in out-of-hospital cardiopulmonary arrest survivors as a simple and useful tool to predict neurological prognosis

The objectives were to analyze the correlation between dynamic changes in NSE and outcomes and to determine the measurement timing that best predicts neurological status.MethodsMulticenter cohort study including patients admitted after shockable rhythm OHCA and treated with MTH. Serum NSE was sampled at 2 different times and Δ-NSE (%) was calculated as 100 x (NSE2-NSE1)/NSE1. In-hospital mortality and neurological outcome, as assessed by the Cerebral Performance Category (CPC) scale, were evaluated during admission and after a 6-month follow-up.ResultsWe included 166 patients admitted to 4 hospitals. In-hospital mortality was 31.9%. Almost 60% of patients had a good neurological recovery (CPC 1-2). On univariate and multivariate logistic regression analyses, an increase in NSE levels was associated with higher in-hospital mortality and worse CPC on discharge and after 6-months (P 
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research

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Publication date: Available online 15 November 2019Source: Wilderness &Environmental MedicineAuthor(s): Jennifer Dow, Gordon G. Giesbrecht, Daniel F. Danzl, Hermann Brugger, Emily B. Sagalyn, Beat Walpoth, Paul S. Auerbach, Scott E. McIntosh, Mária Némethy, Marion McDevitt, Robert B. Schoene, George W. Rodway, Peter H. Hackett, Ken Zafren, Brad L. Bennett, Colin K. GrissomTo provide guidance to clinicians, the Wilderness Medical Society convened an expert panel to develop evidence-based guidelines for the out-of-hospital evaluation and treatment of victims of accidental hypothermia. The guidelines present...
Source: Wilderness and Environmental Medicine - Category: Environmental Health Source Type: research
Publication date: Available online 15 November 2019Source: Medicina Intensiva (English Edition)Author(s): M.L. Avellanas Chavala, M. Ayala Gallardo, Í. Soteras Martínez, E. Subirats BayegoAbstractA narrative review is presented on the diagnosis, treatment and management of accidental hypothermia. Although all these processes form a continuum, for descriptive purposes in this manuscript the recommendations are organized into the prehospital and in-hospital settings.At prehospital level, it is advised to: (a) perform high-quality cardiopulmonary resuscitation for cardiac arrest patients, regardless of body temp...
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
By Irene Mirembe, Knowledge management manager, IntraHealth International The BABIES matrix is a simplified quality-improvement methodology for collecting and displaying data. It was introduced and implemented by the Katakwi Hospital to improve services. Photo courtesy of Irene Mirembe.November 15, 2019Margret Imma from Uganda’s Katakwi District looks lovingly at her 4-month-old, bubbly baby boy, Orisa. He is glowing and Margret couldn’t be happier. This was not the case a few months ago, when Orisa was born too soon.“The pain and suffering that came with handling a preterm baby was unbearable,”...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: Maternal, Newborn, & Child Health Education Performance Midwives Source Type: news
Publication date: Available online 15 November 2019Source: Journal of Thermal BiologyAuthor(s): Jae-Chul Lee, Moo-Ho Won
Source: Journal of Thermal Biology - Category: Biology Source Type: research
A recently published article in Switzerland by Kustermann et al1 has reported a high level of the predictive performance of electroencephalography-based power spectra within 24  h from coma onset in patients following cardiac arrest (CA). The authors evaluated the ability of electroencephalography (EEG) to predict long-term outcomes and claimed that on the first day of coma following CA, low power spectra values around 10 Hz, typically linked to impaired cortico-thalam ic structural connections, are highly specific of unfavourable outcome.
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research
CONCLUSION: The established measures for prevention of perioperative hypothermia in elective procedures are sufficient. However, the local wound surface temperature is not preserved satisfactorily. Deployment of a device for intraoperative insufflation of W-H-CO2 into open wounds may be suitable for maintaining local normothermia. Further studies are needed to determine the influence of warm and humid CO2 on wound healing. PMID: 31726472 [PubMed - as supplied by publisher]
Source: Zentralblatt fur Chirurgie - Category: Surgery Authors: Tags: Zentralbl Chir Source Type: research
In conclusion, this study suggests curcumin as a potent neuroprotective agent with potential for the treatment of HIE. The delayed application of curcumin further increases its clinical relevance.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractBackgroundMelatonin is widely available either on prescription for the treatment of sleep disorders or as an over-the-counter dietary supplement. Melatonin has also recently been licensed in the UK for the short-term treatment of jetlag. Little is known about the potential for adverse events (AEs), in particular AEs resulting from long-term use. Concern has been raised over the possible risks of exposure in certain populations including pre-adolescent children and patients with epilepsy or asthma.ObjectivesThe aim of this systematic review was to assess the evidence for AEs associated with short-term and longer-ter...
Source: CNS Drugs - Category: Neurology Source Type: research
Journal of Perinatology, Published online: 13 November 2019; doi:10.1038/s41372-019-0551-2Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Identification of early signs of hypoxic ischemic encephalopathy (HIE) with magnetic resonance imaging (MRI) has proven of prognostic significance. Yet, the importance of intracranial hemorrhage (ICH), being p...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
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