Role of eating disorders-related polymorphisms in obesity pathophysiology.
Role of eating disorders-related polymorphisms in obesity pathophysiology.
Rev Endocr Metab Disord. 2019 Mar 28;:
Authors: Nicoletti CF, Delfino HBP, Ferreira FC, Pinhel MAS, Nonino CB
Abstract
Human biological system provides innumerable neuroendocrine inputs for food intake control, with effects on appetite's modulation and the satiety signs. Its regulation is very complex, engaging several molecular interactions with many tissues, hormones, and neural circuits. Thus, signaling molecules that control food intake are critical for normal energy homeostasis and a deregulation of these pathways can lead to eating disorders and obesity. In line of this, genetic factors have a significantly influence of the regulation of neural circuits controlling the appetite and satiety pathways, as well as the regulation of brain reward systems. Single Nucleotide Polymorphisms (SNPs) in genes related to hypothalamic appetite and satiety mechanisms, further in multiple neurotransmitter systems may contribute to the development of major Eating Disorders (EDs) related to obesity, among them Binge Eating Disorder (BED) and Bulimia Nervosa (BN), which are discussed in this review.
PMID: 30924001 [PubMed - as supplied by publisher]
Source: ENDOCR REV - Category: Endocrinology Authors: Nicoletti CF, Delfino HBP, Ferreira FC, Pinhel MAS, Nonino CB Tags: Rev Endocr Metab Disord Source Type: research
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