Cochrane seeks Clinical Research Associate - Liverpool, UK

 Liverpool school of Tropical Medicine's Centre for Evidence Synthesis in Global Health has led developments in systematic reviews in tropical medicine and international health. In the 1990s, staff contributed to setting up Cochrane, and established theCochrane Infectious Diseases Group (CIDG). This is now recognised as one of Cochrane's premier groups, with over 150 Cochrane reviews and 600 authors, and is well-linked with the World Health Organization.We are looking to expand the centre. As part of this, we are recruiting staff for the "Research, Evidence and Development Initiative " (READ-It) programme that is just starting, a collaborative five-year programme with partners in South Africa, Zambia, Sri Lanka, India and Nepal. Our priorities are entirely derived from LMIC priorities and develop rapidly. We are seeking to engage the successful applicant in a high-priority area commensurate with their areas of interest and to work with colleagues in partner countries.To illustrate the range of topics, some systematic review topics in the in-tray include:Public health programmes in preventing anaemia, micronutrient supplementation, filariasisDetection and treatment of TBDiagnostic test accuracy reviews in histoplasmosis, HIV, G6PD deficiencyCommunity health workers and mental health promotion and deliveryThere are also a variety of methodological projects related to Cochrane review updating, conflicts of interest, statistical reporting, and methods for moving fr...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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The objective of this study was to describe the socio-demographic and unique morbidity characteristics of this community and their effect on HbA1c measurements. Consanguinity, especially among cousins in the Bedouin population, results in a high prevalence of autosomal recessive genetic diseases such as thalassemia (underestimate of HbA1c), hemoglobinopathies (underestimate and overestimate), Gilbert's disease, and glucose-6-phosphate dehydrogenase deficiency, an X-linked disorder, which can cause hyperbilirubinemia with an overestimate of HbA1c. Furthermore, nutritional deficiencies, autosomal recessive diseases, high bir...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
ema T Abstract Single dose primaquine (PQ) clears mature gametocytes and reduces transmission of Plasmodium falciparum after artemisinin combination therapy. Genetic variation in CYP2D6, the gene producing the drug metabolizing enzyme cytochrome P450 2D6 (CYP2D6), influences plasma concentrations of PQ and its metabolites and is associated with PQ treatment failure in P. vivax Using blood and saliva samples of varying quantity and quality from 8 clinical trials across Africa, (n=1076), we were able to genotype CYP2D6 for 774 samples (72%). We determined whether genetic variation in CYP2D6 has implications for PQ e...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
CONCLUSIONS: Although limited data were available, the analysis did not detect a difference in recurrence between the 7-day regimen and the standard 14-day regimen of 0.5 mg/kg/day primaquine, and no serious adverse events were reported in G6PD-normal participants taking 0.5 mg/kg/day of primaquine. This shorter regimen may be useful in G6PD-normal patients if there are treatment adherence concerns. Further large high-quality RCTs are needed, such as the IMPROV trial, with more standardised comparison regimens and longer follow-up to help resolve uncertainties. PMID: 31274189 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
We report the case of a neonate with a new, previously undescribed, glucose-6-phosphate dehydrogenase (G6PD) gene mutation, which was revealed by severe cholestasis, hyperbilirubinemia, and transient liver dysfunction. The severity of the clinical phenotype with ongoing chronic hemolytic anemia suggests that this mutation belongs to class 1 G6PD deficiency. The hemizygous mutation «c.675G>c; p.Trp225Cys» was detected by genomic sequencing. Since severe G6PD deficiency can be revealed by cholestasis, it is important to check G6PD enzyme activity when faced with a case of liver dysfunction in the neonatal peri...
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
Authors: Goi T, Shionoya Y, Sunada K, Nakamura K Abstract We performed general anesthesia on a 3-year-old boy with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with G6PD deficiency exhibit jaundice and anemia due to hemolysis caused by a lack of the G6PD enzyme. To maintain anesthesia, we used propofol and remifentanil, which may prevent hemolytic attacks by exerting an antioxidant effect. In addition, because the patient was in a high-risk group for the development of methemoglobinemia, we used mepivacaine as a local anesthetic. We liaised with the patient's attending physician to make sufficient ...
Source: Anesthesia Progress - Category: Anesthesiology Tags: Anesth Prog Source Type: research
Abstract OBJECTIVE: Present study was undertaken to study the association between sickle cell anemia (SCA) and glucose-6-phosphate dehydrogenase (G6PD) deficiency from Sahu and Kurmi population of Durg and Rajnandgaon district of Chhattisgarh, India. METHOD: A random sampling of 1749 individuals was done. SCA and G6PD deficiency was detected by slide test followed by electrophoresis and Enzymatic reaction indicated by change in colour respectively. Further the samples were subjected to analyze glutathione-S-transferase (GST) i.e. GSTM1 and GSTT1 gene polymorphism, variance of G6PD among G6PD deficient samples...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
Publication date: Available online 26 April 2019Source: Meta GeneAuthor(s): Eduardo Hernández-Verdin, Andrea Ganelón-Ríos, Guillermo Pettet-Ruiz, Mireya Sánchez-Garza, Joaquín Reinoso-Reyes, Rubén López-RevillaAbstractSulfamethoxazole (SMX) and ciprofloxacin (CPFX), two of the most prescribed antimicrobials worldwide, induce adverse reactions (ADRs) determined by clinically relevant variants of the CYP2C9, CYP2D6, G6PD, GCLC, GSTM1, and NAT2 genes. We designed methods to generate and sequence amplification products to identify the relevant single nucleotide polymorphisms (SN...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Conclusion: From the results obtained, it implies that G6PD deficiency may increase the severity of anaemia in SCD patients. There is therefore the need to screen all SCD patients for G6PD deficiency to ensure that their condition is not exacerbated during treatment. PMID: 31016042 [PubMed]
Source: Anemia - Category: Hematology Tags: Anemia Source Type: research
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionsOur approach could significantly increase the detection rate of male patients and female carriers with a reasonable cost and a reasonable number of clinic referrals.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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