Molecules, Vol. 24, Pages 1153: Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
Molecules, Vol. 24, Pages 1153: Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
Molecules doi: 10.3390/molecules24061153
Authors:
Fatma Tosun
John A. Beutler
Tanya T. Ransom
Mahmut Miski
Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14′-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.
Source: Molecules - Category: Chemistry Authors: Fatma Tosun John A. Beutler Tanya T. Ransom Mahmut Miski Tags: Article Source Type: research
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