Maurocalcine effects on calcium homeostasis in adult rat cardiomyocytes and human iPS cells derived cardiomyocytes

ConclusionOur results demonstrate that MCa penetrates adult cardiomyocytes as well as human iPS derived cardiomyocytes and modulates RyR2 activity. MCa analogues exhibit different effects on RyR2, from positive to negative allosteric modulation. These results provide promising evidence that MCa could be used as an in cellulo modulator of RyR2 to control abnormal RyR activity in pathological situations.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research