Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications

AbstractAllergic eosinophilic esophagitis (EoE) is a chronic, allergen-mediated inflammatory disease of the esophagus, and the most common cause of prolonged dysphagia in children and young adults in the developed world. While initially undistinguished from gastroesophageal reflux disease-associated esophageal eosinophilia, EoE is now recognized as a clinically distinct entity that shares fundamental inflammatory features of other allergic conditions and is similarly increasing in incidence and prevalence. The clinical and epidemiologic associations between EoE and other allergic manifestations are well established. In addition to exaggerated rates of atopic dermatitis, IgE-mediated food allergy, asthma, and allergic rhinitis in EoE patients, each of these allergic manifestations imparts individual and cumulative risk for subsequent EoE diagnosis. As such, EoE may be a member of the “allergic march”—the natural history of allergic manifestations during childhood. Several determinants likely contribute to the relationship between these conditions, including shared genetic, environmental, and immunologic factors. Herein, we present a comprehensive review of allergic comorbi dity in EoE. We discuss areas of the genome associated with both EoE and other allergic diseases, including the well-studied variants encoding thymic stromal lymphopoietin and calpain 14, among other “atopic” regions. We summarize ways that environmental factors (such as microbi...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

CONCLUSIONS: Though RYGB is the best anti reflux procedure it is associated with significant higher morbidity/mortality as compared to SG and OAGB. These two procedures can be used in the majority of patients with GORD and/or HH seeking BMS with an acceptance that some patients will need conversion to RYGB in the long term. PMID: 32773756 [PubMed - as supplied by publisher]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
This study aimed to probe the effect of catalpol, a major component of Radix Rehmanniae Preparata (Shudihuang), on airway remodeling and expression of TGF-β1 and EGF in asthmatic mice. A mice model of asthma was induced by ovalbumin (OVA) treatment. BALB/c mice were randomly divided into blank control group, asthma model group, dexamethasone (DEX) group (positive control), high, medium and low dose of catalpol intervention group. Changes in lung histology were observed using hematoxylin and eosin staining. The levels of TGF-β1 and EGF in mouse sera and bronchoalveolar lavage fluid (BALF) were examined by ELISA. T...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Khan M, Huang YA, Kuo CY, Lin T, Lu CH, Chen LC, Kuo ML Abstract Stressed or injured cells release ATP into the extracellular milieu via the pannexin1 (Panx1) channels, which is the basis of inflammation in a variety of conditions, including allergic lung inflammation. Although the role of Panx1 in mediating inflammation has been well established, the role of its mimetic peptide, 10Panx1, which inhibits ATP release from Panx1 channels, in allergic asthma remains understudied. The aim of this study was to evaluate the effects of using 10Panx1 to inhibit Panx1 channel in a murine model of ovalbumin (OVA)-ind...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: Available online 6 August 2020Source: The Lancet Respiratory MedicineAuthor(s): Elissa M Abrams, Gráinne McGill, Sunil S Bhopal, Ian Sinha, Ricardo M Fernandes
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 9 August 2020Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Muhammed Fatih Dogan, Ali Parlar, Saliha Aysenur Cam, Elif Merve Tosun, Fatma Uysal, Seyfullah Oktay Arslan
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
The term asthma chronic obstructive pulmonary disease (COPD) overlap (ACO) has been popularized to describe people who simultaneously have features of both diseases. Analysis of the basis of disease classification and comparison of the clinical, pathophysiological, and therapeutic features of asthma and COPD concludes that it is not useful to use the term ACO. Rather, it is important to make the individual diagnoses, recognizing that both diseases may coexist. If a concurrent diagnosis of COPD is suspected in people with asthma, pharmacotherapy should primarily follow asthma guidelines, but pharmacologic and nonpharmacolog...
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
Authors: Kang HH, Lim CH, Oh JH, Cho MJ, Lee SH Abstract Background/Aims: As there is insufficient evidence for a relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA), we investigated whether OSA diagnosed by polysomnography (PSG) is related to GERD. Methods: A total of 402 subjects was evaluated. Overnight PSG was performed and a few questionnaires on GERD, anxiety, depression, and daytime sleepiness were administered. An apnea-hypopnea index
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
AbstractAtopic disorders and gastroesophageal reflux disease (GERD) are some of the most common medical conditions treated by primary care physicians and specialists alike. The observation that atopic disorders, like asthma, allergic rhinitis and sinusitis, food allergies, atopic dermatitis, contact dermatitis, and eosinophilic esophagitis are common comorbidities in patients with GERD raises the question of the nature of the relationship that may exist between GERD and atopic disorders. In this article, we review the pathophysiology of GERD, its effect on the immune system, the effect of acid-blocking medications on aller...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusions Inflammation pathway of asthma and recurrent wheeze are related to eosinophil cells in older children and neutrophil cells in younger children. These results could improve personalized treatments.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell li...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
More News: Acid Reflux | Allergy | Allergy & Immunology | Asthma | Child Development | Children | Dermatitis | Dermatology | Environmental Health | Epidemiology | Food Allergy | Gastroenterology | Gastroesophageal Reflux Disease | Genetics | GERD | Hay Fever