Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications

AbstractAllergic eosinophilic esophagitis (EoE) is a chronic, allergen-mediated inflammatory disease of the esophagus, and the most common cause of prolonged dysphagia in children and young adults in the developed world. While initially undistinguished from gastroesophageal reflux disease-associated esophageal eosinophilia, EoE is now recognized as a clinically distinct entity that shares fundamental inflammatory features of other allergic conditions and is similarly increasing in incidence and prevalence. The clinical and epidemiologic associations between EoE and other allergic manifestations are well established. In addition to exaggerated rates of atopic dermatitis, IgE-mediated food allergy, asthma, and allergic rhinitis in EoE patients, each of these allergic manifestations imparts individual and cumulative risk for subsequent EoE diagnosis. As such, EoE may be a member of the “allergic march”—the natural history of allergic manifestations during childhood. Several determinants likely contribute to the relationship between these conditions, including shared genetic, environmental, and immunologic factors. Herein, we present a comprehensive review of allergic comorbi dity in EoE. We discuss areas of the genome associated with both EoE and other allergic diseases, including the well-studied variants encoding thymic stromal lymphopoietin and calpain 14, among other “atopic” regions. We summarize ways that environmental factors (such as microbi...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

ConclusionThis review summarizes research on the traditional use, phytochemistry, biological activities, and toxicology of P. cauliflora. Although P. cauliflora possesses significant biological activities, much of its ethnomedicinal use has not been scientifically evaluated. Well-designed pharmacological and toxicological assays and randomized clinical trials are still needed to validate its ethnopharmacological use as an herbal medicine.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Three medical stories from the week that we didn't cover, explained.Medscape
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Family Medicine/Primary Care Article Source Type: news
Publication date: Available online 15 August 2019Source: Veterinary ParasitologyAuthor(s): Ana Vitória Verde Oliveira Rocha, Brenda Fernanda Sodré Moreno, Aline Diniz Cabral, Nayara Mendes Louzeiro, Leandro Macedo Miranda, Vivian Magalhães Brandão dos Santos, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Arlei Marcili, Márcia Aparecida Sperança, Andréa Pereira da CostaAbstractVisceral leishmaniasis is a zoonotic disease caused by Leishmania infantum for which dogs are the main reservoir. In South America, presence of this disease is expanding along with increasing d...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Skip to content ... Implantes mamarios vinculados a un c áncer poco común se retiran del mercado en todo el mundo ... Los implantes texturizados de Allergan están asociados con más del 80% de los ca...
Source: AARP.org News - Category: American Health Source Type: news
You're reading Testicular pain: Everything you need to know as a parent, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Does your of age son often complain about the pain in testicles? Does he feel uncomfortable while riding his bicycles or bike? If yes! It could be testicular pain which mostly occurs among teenage boys.  It’s very uncommon to see the pain in boys above 25 years old. Testicular pain often requires immediate medical attention. If the treatment is started within 6 hrs of beginning of the pain, ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Causes of Testicular Pain in Children Kidshealth Testicle Pain Testicle Pain in Children Testicular Pain in Kids Source Type: blogs
Find out how the safety profile for abatacept compared with that of other DMARDs for rheumatoid arthritis.Arthritis Research &Therapy
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Rheumatology Journal Article Source Type: news
Updated Date: Fri, 16 Aug 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
AbstractAtopic disorders and gastroesophageal reflux disease (GERD) are some of the most common medical conditions treated by primary care physicians and specialists alike. The observation that atopic disorders, like asthma, allergic rhinitis and sinusitis, food allergies, atopic dermatitis, contact dermatitis, and eosinophilic esophagitis are common comorbidities in patients with GERD raises the question of the nature of the relationship that may exist between GERD and atopic disorders. In this article, we review the pathophysiology of GERD, its effect on the immune system, the effect of acid-blocking medications on aller...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusions Inflammation pathway of asthma and recurrent wheeze are related to eosinophil cells in older children and neutrophil cells in younger children. These results could improve personalized treatments.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell li...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
More News: Acid Reflux | Allergy | Allergy & Immunology | Asthma | Child Development | Children | Dermatitis | Dermatology | Environmental Health | Epidemiology | Food Allergy | Gastroenterology | Gastroesophageal Reflux Disease | Genetics | GERD | Hay Fever